Crouzon‐like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3Fgf4 locus
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چکیده
منابع مشابه
A transgene insertional mutation at an imprinted locus in the mouse genome.
Genetic imprinting in mice results in functional differences in the oocyte and spermatocyte genomes, as evidenced by both genetic and pronuclear transfer experiments. To gain insights into the molecular mechanisms involved in the imprinting process, researchers have studied methylation phenotypes and expression of hemizygous transgenes associated with parental origin. In this report, we describ...
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Pod corn (Zea mays var tunicata) was once regarded as ancestral to cultivated maize, and was prized by pre-Columbian cultures for its magical properties. Tunicate1 (Tu1) is a dominant pod corn mutation in which kernels are completely enclosed in leaflike glumes. Here we show that Tu1 encodes a MADS box transcription factor expressed in leaves whose 5' regulatory region is fused by a 1.8-Mb chro...
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Insertional mutation on mouse chromosome 18 with vestibular and craniofacial abnormalities.
A dominant mutation was generated in transgenic mice as a consequence of insertional mutation. Heterozygous mice from transgenic line 9257 (Tg9257) are hyperactive with bidirectional circling behavior and have a distinctive facial appearance due to hypoplasia of the nasal bone. Morphological analysis of the inner ear revealed asymmetric abnormalities of the horizontal canal and flattening or in...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1998
ISSN: 1058-8388,1097-0177
DOI: 10.1002/(sici)1097-0177(199806)212:2<242::aid-aja8>3.3.co;2-z